ea0029oc13.5 | Adrenal Basic | ICEECE2012
Yamada M.
, Taguchi R.
, Nakajima Y.
, Satoh T.
, Hashimoto K.
, Shibusawa N.
, Ozawa A.
, Tomaru T.
, Okada S.
, Rokutanda N.
, Takata D.
, Koibuchi Y.
, Horiguchi J.
, Oyama T.
, Takeyoshi I.
, Mori M.
Background: Primary aldosteronism (PA) has been reported to affect about 10% of patients with essential hypertension. In Western countries, about one third of them have aldosterone-producing adenomas (APA), and mutations of the KCNJ5 gene have recently been identified in approximately 30% of APAs. In contrast, most Japanese (~80%) with PA have APA. Therefore, Japanese PA may have different characteristics from patients in Western countries, and those with mutations of the KCNJ...